Mitotherapy involving repetitive injections after CLP led to a restoration of gene expression levels of SIRT-1 (P=0.0262 vs Sepsis group), PGC-1α (P=0.0191 vs Sepsis group), and Mfn2 (P=0.0175 vs Sepsis group), bringing them closer to the levels observed in the pre-damage state (Figure 4A, B, E). The gene discussed is SIRT1; the disease is Sepsis.