His lab described novel somatic and germline mutations in c-KIT and KRAS with intracranial germ cell tumors.24 This work led to discussions on how to complement the tissue diagnosis with cerebrospinal fluid (CSF) or plasma/serum profiling, finding CSF as a better choice due to its contact to the tumor, lower contamination, and harboring more tumor-related DNA. Here, KRAS is linked to neoplasm.