In addition, tetrandrine showed an anticancer activity regarding CRC as it suppressed the growth of colon cancer IL‐6 induced HCT116 cells and triggered apoptosis by upregulating the expression of TGF‐β1 through the downregulation of the MMP‐2 activity and restoration of the E‐cadherin gene promoter activity [149, 150]. The gene discussed is TGFB1; the disease is colorectal carcinoma.