Oxymatrine is the main ingredient of a Chinese herb Sophora flavescens Ait, that is widely used in traditional Chinese therapy [147]. It inhibits the formation of CRC and its migration through the ruling of the level of expression of TGF‐β1, Smad4, and pSmad2 by inhibiting P38‐dependent expression of PAI‐1. This evidence concerns the gene TGFB1 and colorectal carcinoma.