Cytokine production plays a crucial rolein controlling parasitemiaand is modulated by parasite load. Highparasitemia has been shown to trigger stronger immune responses thatcan alternate between pro-inflammatory and protective effects, whereaslow parasitemia tends to induce moderate immune activation. Memory T cells are essential for sustained protection,driven in part by the continued presence and activity of IFN-γ-producingT cells. The gene discussed is IFNG; the disease is parasitic infectious disease.