IFNG and malaria: Progression to severe malaria cases can occur when the innateimmuneresponse is insufficient to eliminate the parasite, requiring theadaptive immune system to act as a defense and to modulate inflammationto prevent excessive host injury.,,−,  An intense inflammatory response,marked by interferon-gamma (IFN-γ), inhibits red blood cellproduction and promotes precursor apoptosis, thereby worsening anemia.,, Conversely, the adaptive immuneresponse in controlling parasitemia can lead to excessive red bloodcell removal, further destroying uninfected erythrocytes.