,23 The anomalous activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and Wnt/β-catenin signaling pathway plays a vital role in the occurrence, progression, and drug resistance of HCC (Fig. 1).24, 25, 26, 27 In addition, HBx can interfere with the repair of damaged DNA, driving tumor development.28 Here, AKT1 is linked to neoplasm.