Furthermore, the AUCs of circ-0028861 plus AFP (0.91, 0.82, and 0.86, respectively) were higher than those of AFP (0.82, 0.69, and 0.76, respectively) for distinguishing HBV-HCC from chronic HBV infection, HBV without cirrhosis, and hepatitis B with cirrhosis. The gene discussed is AFP; the disease is hepatocellular carcinoma.