Tian et al have shown that METTL3 promotes the stability of brain-derived neurotrophic factor (BDNF) mRNA via an m6A/IGF2BP1-mediated manner, followed by the activation of BDNF/TRKB signaling pathway, which is a positive regulator of epithelial–mesenchymal transition, thus increasing the metastatic potential of endometrial cancer cells.96 The gene discussed is BDNF; the disease is endometrial cancer.