,221 Similarly, IGF2BP1 can increase the mRNA stability and expression levels of various target genes related to cell proliferation by specifically binding to their mRNAs, thereby promoting neuroblastoma cell proliferation and inducing chemotherapeutic agent resistance, including cisplatin, cyclophosphamide, doxorubicin, etoposide, and topotecan.222. The gene discussed is IGF2BP1; the disease is neuroblastoma.