Gao et al found that the METTL3/m6A/IGF2BP1 axis is crucial for stabilizing the mRNA of nuclear factor of activated T cells 5 (NFAT5), which can up-regulate the expression of the gluconeogenesis-related genes glucose transporter type 1 (GLUT1) and phosphoglycerate kinase 1 (PGK1), thereby promoting glycolytic reprogramming in intrahepatic cholangiocarcinoma.99 The gene discussed is NFAT5; the disease is intrahepatic cholangiocarcinoma.