In NSCLC, RCC, and ovarian cancer, m6A/IGF2BP1 mediated mRNA stabilization of thymidine kinase 1 (TK1), sphingosine-1-phosphate-receptor 3 (S1PR3), and ubiquitin-like modifier activating enzyme 6 (UBA6),69, 70, 71 while in HCC, ALKBH5-mediated m6A demethylation could suppress the IGF2BP1-mediated LYPD1 mRNA stabilization, thereby decreasing the proliferation potential of HCC cells.72 The gene discussed is S1PR3; the disease is non-small cell lung carcinoma.