ESRRA and osteosarcoma: Moreover, IGF2BP1 suppresses estrogen-related receptor alpha (ERRα) mRNA decay by directly binding to its 3′-UTR in an m6A-dependent manner, subsequently enhancing oxygen consumption rate, ATP levels, glucose consumption, and lactate production of osteosarcoma cells, and thus contributes to osteosarcoma cell resistance to doxorubicin.98