Moreover, IGF2BP1 suppresses estrogen-related receptor alpha (ERRα) mRNA decay by directly binding to its 3′-UTR in an m6A-dependent manner, subsequently enhancing oxygen consumption rate, ATP levels, glucose consumption, and lactate production of osteosarcoma cells, and thus contributes to osteosarcoma cell resistance to doxorubicin.98 This evidence concerns the gene IGF2BP1 and osteosarcoma.