Down-regulation of SYVN1 leads to the accumulation of NLR family pyrin domain containing 3 (NLRP3) protein by suppressing its ubiquitination/proteasomal degradation, leading to the activation of NLRP3/IL-1β/Smad2/3 axis, and eventually, epithelial–mesenchymal transition in cervical cancer.93 Here, NLRP3 is linked to cervical carcinoma.