CD8A and hepatocellular carcinoma: This subsequently deteriorates the immune escape and CD8+ T cell-mediated tumor cytotoxicity and apoptosis in colon cancer, GC, HCC, and bladder cancer.104, 105, 106, 107 Meanwhile, Zhai et al elucidated that IGF2BP1 promotes the mRNA stability of axis inhibitor 2 (AXIN2), a vital regulator of the Wnt/β-catenin signaling pathway, in an m6A-dependent way.