FOXO1 and rhabdomyosarcoma: Milewski et al77 found that PAX3-FOXO1 fusion protein is a key oncogenic driver of rhabdomyosarcoma, and PAX3-FOXO1 knockdown reduced FOXF1 mRNA and protein expression in RH4 and RH18 FP-RMS cells, which in turn regulates the development of rhabdomyosarcoma.