Similar pathogenic fusion genes are found in leukemias, such as AML1 (acute myeloid leukemia-1)-ETO (eight twenty-one), PML (promyelocytic leukemia)-RARα (retinoic acid receptor alpha), and ETV6 (ETS variant transcription factor 6)-RUNX1 (RUNX family transcription factor 1). The gene discussed is RUNX1; the disease is leukemia.