AKT1 and neoplasm: This fusion gene produces a fusion protein with kinase activity that activates multiple signaling pathways, including JAK (Janus kinase)/STAT (signal transducer and activator of transcription), PI3K (phosphoinositide 3-kinase)/AKT (protein kinase B), and RAS/MAPK (mitogen-activated protein kinase), to promote tumor cell growth and survival (Fig. 2).