In HCC, the up-regulation of the lncRNA HULC (hepatocellular carcinoma up-regulated long noncoding RNA) was associated with the depletion of IGF2BP1, which recognizes m6A-modified HULC molecules and recruits the CCR4-NOT complex to initiate HULC degradation. The gene discussed is IGF2BP1; the disease is hepatocellular carcinoma.