Another lncRNA, RUNX1-IT1 (intronic transcript 1), which is derived from intron 1 of RUNX1, can inhibit the Wnt/β-catenin signaling pathway through the RUNX1-IT1/miR-632/GSK-3β (glycogen synthase kinase 3 beta) cascade, thereby impeding the proliferation, cell cycle progression, metastasis, and invasion of HCC cells. This evidence concerns the gene RUNX1 and hepatocellular carcinoma.