They show a senescence-associated secretory phenotype (SASP), which means they release cytokines or CXCs or inflammatory immune mediators, such as CXCL1 and CXCL8/IL-8, that may help tumors grow by creating a tumorigenic environment.84, 85, 86 Eventually, as people age, their immune systems deteriorate, making it challenging to create an effective immune response against developing cancers.87 The gene discussed is CXCL1; the disease is cancer.