Because IL-6 and IL-8 potentiate each other's biological effects and alter the activity of steroidogenesis enzymes, they can have a direct or indirect impact on the expression of estrogen, progesterone, and HER2 receptors by tumor cells in IBC NST of the luminal B HER2-positive subtype.58, 59, 60, 61. The gene discussed is ERBB2; the disease is neoplasm.