Previous molecular dynamics and docking studies have been applied to predict the interactions between various ligands and protein fibrils.22,32–34 While the binding site of an analogue of BF-79 has been proposed on α-synuclein fibrils formed in vitro,22 the morphology and heterogeneity of α-synuclein found in serum samples from PD patients is unknown. This evidence concerns the gene SNCA and Parkinson disease.