This process triggers tau hyperphosphorylation and facilitates Aβ aggregation through the enhanced activation of glycogen synthase kinase 3β (GSK-3β) and β-secretase (BACE1), which contribute to the hallmark neurofibrillary tangles and plaques found in AD brains (Krishaa et al., 2023; Kumari et al., 2023; Leng and Edison, 2021; Lian et al., 2016; Mayne et al., 2020; Santello et al., 2019; Teleanu et al., 2022a; Tilleux and Hermans, 2007; Wu and Eisel, 2023). The gene discussed is MAPT; the disease is Alzheimer disease.