The interaction between Aβ, tau, and immune activation creates a vicious cycle, where inflammation promotes further tau pathology, and tau toxicity worsens inflammation, ultimately leading to neuronal death and cognitive decline (Bano et al., 2024; Chitnis and Weiner, 2017; Kang et al., 2009; Kempuraj et al., 2016; Leng and Edison, 2021). This evidence concerns the gene MAPT and Mental deterioration.