TPO and cryohydrocytosis: Several studies have suggested a link between CHC and thyroid dysfunction, with CHC patients having higher levels of T3 and T4, anti-thyroid peroxidase antibodies, anti-thyroglobulin antibodies, subclinical and overt hypothyroidism (Antonelli et al., 2004; Indolfi et al., 2008; Danilovic et al., 2013).