Hence, compared to the 2002 Czech nationwide screening program, we did not detect a single misdiagnosed case of FD in ESKD, which could be due to the “classical” lysosome dysfunction-based pathogenesis that could be laboratory-substantiated by altered GALA activity and/or lyso-Gb3 biomarkers (Tables 2 and 3). The gene discussed is GLA; the disease is Fabry disease.