Previous studies have reported age-related loss of BDNF expression in the cochlea, highlighting the importance of considering age-related factors in the development of therapeutic interventions for hearing loss.10 The gradual decline in BDNF expression during the later stages of life underscores the need for early-intervention strategies to preserve auditory function and mitigate age-related cochlear degeneration. The gene discussed is BDNF; the disease is hearing loss disorder.