Among previous studies addressing this subject, one study using the Copenhagen General Population Study demonstrated higher plasma urate to be causally associated with cancer incidence (OR = 1.22) and all-cause mortality (OR = 1.49) using only rs7442295 in SLC2A9 gene as an instrument for urate (36), while one showed causal association of higher urate with higher risk of prostate cancer in Japanese population using 34-SNP urate instrument (37). Here, SLC2A9 is linked to Familial prostate cancer.