NKG2D is expressed on the surface of NK cells and plays a crucial role in the immune recognition of tumor cells.[41] Identifying small molecules that can bind and modulate NKG2D activity is a promising strategy to generate fully synthetic immunostimulatory agents,[37, 38] which could present a superior penetration as compared to antibodies in solid tumors[13, 15] and, therefore, better efficacy. This evidence concerns the gene KLRK1 and neoplasm.