KLRK1 and neoplasm: NKG2D, an activating receptor on NK cells, plays a critical role in identifying and eliminating tumor cells.[41] Despite the challenges they pose for DEL screening, these membrane‐associated targets have been prioritized due to their therapeutic relevance in the field of oncology[21, 30, 32, 41] and the presence of druggable pockets suitable for small organic molecules.[22, 32, 42, 43]