AHR and neoplasm: A prior study demonstrated that I3A functions as an aryl hydrocarbon receptor (AhR) agonist, leading to the induction of AhR downstream genes for immune modulation.[29] Treatment with I3A resulted in the activation of an XRE‐Luc reporter plasmid, indicating transcriptional activation of AhR by I3A in B16‐OVA tumor cells.