Tau is a monomeric andintrinsically disordered protein and may aggregate via nucleationprocesses, forming larger assemblies including oligomeric speciesand eventually insoluble fibrils as part of the pathogenesis., The Tau fibril structures comprise a core with a cross-β structureand an unstructured fuzzy coat. Tau proteinalso misfolds and aggregates in several other diseases besides AD,generally termed tauopathies, outliningTau aggregation, in particular toxic nucleation pathways and/or species,as a potential common target for therapeutic agents for this class of diseases. Here, MAPT is linked to Alzheimer disease.