Since Bri2 BRICHOS exhibitsproperties shared with those of other LLPS and fibrillation modulators,parts of our current findings may be transferable to other systems.The dual effect of Bri2 BRICHOS on Tau and Aβ, both implicatedin AD, provides a tool to target several pathogenic proteins withthe same molecular chaperone. Here, MAPT is linked to Alzheimer disease.