Besides, 52 exonic mutations, 734 copy number variations (CNVs), and 2519 differentially expressed genes (DEGs) are discovered which are enriched in the suppressed DNA damage repair pathways and the activated lung cancer related signaling pathways including JAK‐STAT, PI3K‐Akt, MAPK in the DEE‐induced malignant transformed cells. Here, AKT1 is linked to lung carcinoma.