Notably, both mechanical and biochemical activations of Piezo1 upregulate the expression of PD‐L1 and secretion of CXCL10 in NSCLC cells through YAP activation mediated by p‐FAK (Figures 2c‐i,l and 4b‐f,i), and hence improve immunotherapy response. Here, PTK2 is linked to non-small cell lung carcinoma.