Our study shows that cyclic stretch increases the expression of PD‐L1 (Figure 2c; Figure S5a, c, Supporting Information) and secretion of CXCL10 (Figure 2l; Figure S11b, Supporting Information), fostering a “hot” TIME in primary tumors with improved immunotherapy response, as shown in the clinical analysis of primary and liver metastasis NSCLC patients (Figure 1b). The gene discussed is CXCL10; the disease is metastasis.