PIEZO1 and central nervous system cancer: For example, elevated Piezo1 expression has been linked to decreased patient survival in multiple cancer types (e.g., colon cancer and glioma).[38, 58, 59] Conversely, NSCLC patients manifesting higher Piezo1 expression are shown to own better survival, and loss of Piezo1 is proven to accelerate NSCLC progression and NSCLC cell migration.[60] Hence, the multifaceted character of Piezo1 cannot be overlooked in its clinical translation although Piezo1 is a negative regulator of NSCLC progression.