TGFB1 and lung cancer: Moreover, cyclic stretch affects immune dynamics and cell activity through mechanotransduction in disease and cancer.[43] Such mechanical cue can trigger the release of the NLRP3 inflammasome, a lung cancer promoting protein complex,[44] by epithelial cells after lung injury,[45] which facilitates TGF‐β1 secretion from mast cells in the development of lung fibrosis.[46]