In this study, it is demonstrated that both mechanical and biochemical activation of the mechanosensitive ion channel Piezo 1 induces nuclear translocation of YAP, thereby promoting an immunotherapy‐responsive tumor immune microenvironment (TIME) through enhanced expression of PD‐L1 and secretion of chemokine C‐X‐C ligand 10 (CXCL10, chemokine recruiting CD8+ T cells) in NSCLC cells. The gene discussed is CXCL10; the disease is non-small cell lung carcinoma.