Notably, both mechanical and biochemical activations of Piezo1 upregulate the expression of PD‐L1 and secretion of CXCL10 in NSCLC cells through YAP activation mediated by p‐FAK (Figures 2c‐i,l and 4b‐f,i), and hence improve immunotherapy response. The gene discussed is PIEZO1; the disease is non-small cell lung carcinoma.