The observed phenomenon is consistent with previous findings.[26] Several studies have suggested that PD‐L1 expression and CD8+ T cell infiltration status of LM can forecast their response to anti‐PD‐1/PD‐L1 immunotherapy.[27] Analysis of these markers in our histological samples revealed that the TIME of LM sites presents a “cold” tumor state, characterized by fewer PD‐L1‐positive cells (PD‐L1 expression status confirmed by two senior pathologists) (Figure 1d,e) and lower CD8+ T cell infiltration (Figure 1d,f,g) compared to PL sites. This evidence concerns the gene CD8A and neoplasm.