DRD2 and arthritic joint disease: found that dopamine activates dopamine D2 receptors (DRD2) and significantly increases bone mineralization in osteoblasts without altering the expression of osteoclast markers in arthritis.[24] In addition, DA promotes osteoblast differentiation in a DRD1‐dependent manner via the ERK1/2 signaling pathway.[25] While multiple DA receptor subtypes exist, DRD1 has shown unique regulatory potential in bone metabolism, warranting focused investigation.