To assess whether ALS‐/FTD‐associated TDP‐43 mutations influence GAP43 splicing, we co‐transfected pEGFP‐4a1 with various mutant TDP‐43 constructs, including TDP‐43A90V, TDP‐43K263E, TDP‐43G295S, TDP‐43G295R, TDP‐43M311V, TDP‐43A315T, TDP‐43Q311K, and TDP‐43M337V, and analyzed RT‐PCR results. This evidence concerns the gene TARDBP and frontotemporal dementia.