Both GABRA3-shRNA and GABRA3-CRISPR/Cas9 in MDA-MB231 cells consistently reduced cell invasion caused by BZDRs (Fig. 5A, 5B) (* p < 0.05; ** p < 0.01; *** p < 0.005), confirming that GABRA3 plays a pivotal role in promoting cancer progression in BZDR-mediated cancer signaling, during BRCA progression. The gene discussed is GABRA3; the disease is cancer.