Shi et al. reported that ASGR1 modulates the levels of interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) through the nuclear factor-kappa B/activating transcription factor 5 (NF-κB/ATF5) pathway, resulting in sepsis-induced liver damage [6]. The gene discussed is ATF5; the disease is Sepsis.