The proteins more proteolytically degraded in our analysis were fibrinogen, hemoglobin, several mitochondrial proteins, and two important proteins to maintain the body-fluid homeostasis (Na+/K+ transporting ATPase subunit alpha 1 and Na(+)/H(+) exchange regulatory cofactor NHE-RF3), whose loss is also involved in kidney injury (56, 57). The gene discussed is XK; the disease is kidney injury.