The distinction between classic SSJ-NET and lupus with SSJ-NET-like lesions relies on clinical history (latency of exposure to the suspected drug), seroimmunological criteria (ANA+), and lesion distribution (photodistribution in SLE, trunk predominance in SSJ-NET).2, 3 Anatomopathological criteria can provide additional insights, although findings in these entities often overlap.1, 3. The gene discussed is BTG3; the disease is systemic lupus erythematosus.