Since then, many TSGs have been discovered, such as DNA repair proteins like MutL Homolog 1 (MLH1), cell cycle inhibitors like cyclin-dependent kinase inhibitor 2 (CDKN2), angiogenesis blockers like Von Hippel-Lindau (VHL) tumor suppressor, and cell adhesion molecules like CDH1 (cadherin-1)79. The gene discussed is VHL; the disease is neoplasm.