EPAS1 and hepatocellular carcinoma: Histone acetylation states in cancer are impacted by metabolic reprogramming, which modifies absolute acetyl-CoA and the ratio of acetyl-CoA to coenzyme A. Owing to its ability to produce acetyl-CoA via ligating acetate and CoA, ACSS2 can cause HIF-2α to become acetylated, which inhibits EMT in Hepatocellular Carcinoma (HCC) when oxygen levels are low96.