MTOR and ischemia: These results suggested ischemia following dMCAO significantly provoked neuronal apoptosis, while S.t-ΔpGFGF21 injection dramatically promoted local high concentration of FGF21 and inhibited neuronal apoptosis by up-regulation of autophagy through AMPK/mTOR signal pathway, while the application of autophagy inhibitor 3-MA reverse this neuroprotective effect, indicating the pivotal role of autophagy in ischemia stroke induced neural apoptosis through FGF21/AMPK/ mTOR pathway.