FGF21 can inhibit neuronal apoptosis caused by hypoxic-ischemic brain injury in neonatal rats [25], protect and repair damaged neurons in a rat model of ischemia followed by reperfusion [63], attenuate disruption of the blood-brain barrier after cerebral infarction in diabetic mice, reduce the infarct size [26], and promote recovery of neurological function after MCAO in mice [27]. This evidence concerns the gene FGF21 and ischemia.