TREX1 and central nervous system cancer: TREX1 loss was significantly associated (log-rank p < 0.05) with worse prognosis in acute myeloid leukemia (OS), bladder urothelial carcinoma (PFS), colorectal cancer (OS and PFS), kidney papillary cell carcinoma (OS and PFS), lower grade glioma (PFS), uterine corpus endometrial carcinoma (OS and PFS), and uveal melanoma (OS and PFS).