Of note, two hepatocellular carcinoma samples in TCGA carried the L44P TREX1b protein sequence variant, while organoids from two gastric adenocarcinoma patients carried the C99R variant (Tables S7, S8, S10, and S14), suggesting a possibility of associations of specific TREX1 variants with specific tumor histologies. Here, TREX1 is linked to hepatocellular carcinoma.