Frequent concurrent loss of TREX1 with adjacent genes provides the likely explanation for the poor prognosis of patients carrying a TREX1 deletion in LAML, BLCA, COADREAD, KIRP, GBM, UCEC, and UVM tumors (Fig. S10) and is consistent with previous reports of poor survival outcomes in patients with uveal melanoma who lost the chromosomal region containing the BAP1 gene at 3p21.1 [57, 121, 122]. Here, BAP1 is linked to uveal melanoma.