TREX1 and autoimmune disease: Notably, many variants with reported pathogenic effects in patients with autoimmune disease (e.g., D18N, R114H, V201D) and many other protein-altering variants which interfere with TREX1 function [8, 10, 27] were not reported in any TCGA or COSMIC cancer samples (Tables S7, S8, S10 and S14).