Based on the importance of TREX1 in the control of immune activation, and the role of inflammation and interferon response in neurological, neurodegenerative, and musculoskeletal disorders and in clinical treatment [19, 20, 123–125], future studies may investigate whether TREX1 variants may play contributing or modifying roles in a broad range of diseases that involve inflammatory processes. This evidence concerns the gene TREX1 and musculoskeletal system disorder.