TREX1 and cancer: Additionally, many structural variants, including both cnLOH variants nsv2768229 and nsv2768230 in PLD, and many copy number alterations of TREX1 in cancer also involve, e.g., RASSF1 (RASSF1A), TUSC2 (FUS1), NPRL2, CYB561D2 (101F6) at 3p21.3, BAP1 at 3p21.1, and other important genes at 3p (Table S17), which may contribute to the molecular impact of such events [54–57, 114, 121].