Liao et al.76 report that in a murine model of Parkinson’s disease, overexpression of HSF1 represses microglia polarization, increases the abundance of anti-inflammatory markers (transforming growth factor 1 beta and interleukin 10), and decreases the abundance of pro-inflammatory markers (interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha (TNFα)), when compared to Parkinson’s disease-induced microglia. Here, TNF is linked to Parkinson disease.