Rare predicted damaging variants in the TRIO gene are linked to autism spectrum disorder (ASD), bipolar disorder (BP), intellectual disability (ID), developmental delay (DD), and schizophrenia (SCZ) and have also been observed in epilepsy (Epi) (37, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56). Here, TRIO is linked to epilepsy.