Rare predicted damaging variants in the TRIO gene are linked to autism spectrum disorder (ASD), bipolar disorder (BP), intellectual disability (ID), developmental delay (DD), and schizophrenia (SCZ) and have also been observed in epilepsy (Epi) (37, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56). This evidence concerns the gene TRIO and schizophrenia.