MYCN and neuroblastoma: It is widely recognized that human neuroblastomas consist of 2 epigenetically regulated cell types: adrenergic/noradrenergic and mesenchymal/neural crest cell-like (NCC-like) cell types.38,39 We assessed signature scores for these cell-type-specific genes and found that MYCN+ neuroblasts predominantly expressed adrenergic/noradrenergic signatures but not mesenchymal/NCC-like signatures (Supplementary Figure S2D).