Lastly, we investigated the clinical relevance of Th-MYCN+/− neuroblastoma subtype signatures in human neuroblastoma utilizing the expression dataset from a large neuroblastoma cohort (Kocak cohort, GSE45547).27 Signature scores for uncommitted genes (46 genes) and malignant neuroblast genes (125 genes) were computed for each tumor. Here, MYCN is linked to neuroblastoma.