For instance, MALAT1, a long non-coding RNA, plays a role in cell migration and invasion,40 as well as in neuronal differentiation.41 Both PCP4 and RTN1 are associated with neuroblastoma.42,43 Furthermore, KLF4 and RUNX1 are expressed in favorable neuroblastomas, and their expression is known to suppress neuroblastoma cell growth.44,45 Therefore, these genes might play pivotal roles in promoting the uncommitted population, potentially leading to pre-cancerous spontaneous regression. The gene discussed is KLF4; the disease is neuroblastoma.