In vivo experiments have confirmed a tumor-promoting role for enteric glial cells in CRC development by showing an increase in tumor size in mice when CRC cells were injected together with enteric glia,22 and a reduced tumor burden in mice with glial fibrillary acidic protein (GFAP) promotor-driven depletion of enteric glia.27 Here, GFAP is linked to colorectal carcinoma.