MOC1 is immunologically ‘‘hot,’’ with high CD8+ T cells and major histocompatibility complex (MHC) class I, while MOC2 and P029, with their regulatory T cell (Treg) infiltration, lower MHC class I expression, and myeloid enriched, represent a more immunosuppressive, or ‘‘cold,’’ TME.16 These models represent the diverse human papillomavirus-negative (HPV−) head and neck squamous cell carcinoma (HNSCC) with heterogeneity in mutational signature. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.