Nian et al. (2024) suggested that the interplay between SLE and COVID-19 drives the activation of the JAK-STAT signaling pathway triggered by IFN-I/II in monocytes/macrophages. Wang et al. (2022b) discovered that the genome-wide genetic association signal for severe COVID-19 is linked to that of SLE. Here, SOAT1 is linked to systemic lupus erythematosus.