Using transcriptomic data and multi-omics, drug-specific transcription and/or DNA methylome signatures for the anti-TNF response have been identified in RA synovium and blood-derived immune cells from affected patients, allowing a prediction of the response to anti-TNF drugs in RA therapy (Aterido et al. 2019; Tao et al. 2021). The gene discussed is TNF; the disease is rheumatoid arthritis.