Another research studying the effect of alizarin on pancreatic cancer reported G2/M phase arrest where the proapoptotic protein cleaved caspase 3 was upregulated in contrast to the antiapoptotic-related proteins p-p65, XIAP, Bcl- 2, and c-myc (Xu et al. 2022). This evidence concerns the gene XIAP and familial pancreatic carcinoma.