Supporting the outcomes of the current study, it was shown that NVP-CGM097 induced apoptosis increasing p53 acetylation/activation and cell cycle arrest in G1 and G2, in wild-type p53 ER-positive breast cancer cell line (MCF- 7 and ZR75 - 1) models (Portman et al. 2020). The gene discussed is TP53; the disease is breast carcinoma.