The absence of bromodomain and WD repeat domain containing 1 (BRWD1) led to infertility in both sexes of mouse, and it was revealed that in GV oocytes of the Brwd1 knockout mouse, Mll5 and Prmt8 expression were significantly increased and resulted in a dramatically decreased maturation rate due to increased chromosome instability compared with wild type (Pattabiraman et al. 2015). Here, BRWD1 is linked to Infertility.