Of these three cases, one patient had neuropathy possibly due to renal failure but with an abnormal IENFD and TTR amyloid positivity on biopsy, one patient with neuropathy and co‐existent DM had TTR amyloid positivity on biopsy and one patient with possible chemotherapy induced peripheral neuropathy had TTR amyloid positivity on biopsy. This evidence concerns the gene TTR and Renal insufficiency.