It has been shown that NRG1 promotes angiogenic differentiation of PLSCs and upregulates CD31 to promote vascularization.35 NRG1 promotes myocardial angiogenesis in rats with diabetic cardiomyopathy.39 Bone marrow stem cells overexpressing NRG1 favor angiogenesis in ischemic skeletal muscle.40 In this study, NRG1 knockdown inhibited angiogenesis, suggesting that NRG1 deficiency affects angiogenesis. This evidence concerns the gene PECAM1 and diabetic cardiomyopathy.