In non‐small cell lung cancer, the circular RNA circGLIS3 acts as a molecular sponge for miR‐644a and binds to miR‐644a to up‐regulate the expression of PTBP1, while PTBP1 binds to the flanking introns of circGLIS3 and promotes the cyclization of circGLIS3, forming a circGLIS3/miR‐644a/PTBP1 positive feedback loop that promotes the progression of non‐small cell lung cancer [85]. The gene discussed is PTBP1; the disease is lung cancer.