In particular, in cancer cells, glycolysis is the most critical process that PTBP1 is involved in regulating, and PTBP1 promotes the expression of the M2 isoform of pyruvate kinase (PKM2) while decreasing the expression of PKM1, which mainly leads to a shift from oxidative phosphorylation metabolism to glycolytic metabolism and affects tumorigenesis in cancer cells [34]. Here, PKM is linked to cancer.