Studies in BCP models revealed that specific annexin A3 (ANXA3) knockdown in microglia significantly inhibits the hypoxia inducible factor-1α/vascular endothelial growth factor (HIF-1α/VEGF) signaling pathway, which reduced p-protein kinase C (PKC) levels in spinal cord neurons, leading to marked attenuation of cancer progression-related nociceptive responses [136]. The gene discussed is ANXA3; the disease is cancer.