To identify stem-like cells in the dimensional space, we used the set of 601 differentially expressed marker genes (log2FC > 0.5, padj < 0.05) of the previously defined stem-like cell population of the TAL1 samples (Fig. 2i and Supplementary Data 3) to create a T-ALL ‘stemness’ signature (Supplementary Methods), and scored each cell according to their relative expression of stemness genes (i.e., the stemness score) (Fig. 3d, e and Supplementary Methods). Here, TAL1 is linked to acute lymphoblastic leukemia.