In addition, the reported predictors affecting OS among different studies are either patient-related factors (age, sex, race, PS, underlying liver disease etiology, albumin-bilirubin grade, neutrophil-to-lymphocyte ratio, Child–Pugh score, AFP, body mass index), tumor-related factors (number and size of the lesions, BCLC staging, extrahepatic spread, vascular invasion, and sorafenib dosage21,22,26–28. The gene discussed is AFP; the disease is neoplasm.