Banjerdpongchai et al.35 provided another confirmation when Hesp was found to be effective against hepatocellular carcinoma by inducing apoptosis of human HepG2 cells via mitochondrial and death receptor pathways. The results of immunohistochemistry came into line with the recorded histopathological changes of hepatic tissue which revealed that hesperidin greatly improved the alterations observed in hepatic histoarchitecture due to EAC induction either when used for protection or combined with Cis as a treatment. This evidence concerns the gene TMPRSS11A and hepatocellular carcinoma.