To assess the relationship between changes in ApoM levels and key outcomes (log NT-proBNP, 6-minute walk test, weight, and KCCQ scores), we initially used a linear regression model adjusting for baseline values of each respective outcome, baseline ApoM/S1P levels, age, race/ethnicity, sex, eGFR, and T2DM. This evidence concerns the gene NPPB and type 2 diabetes mellitus.