CDH2 and cardiac hypertrophy: Although N-cadherin (CDH2) is more abundant in the heart and plays a critical role in intercalated disk assembly, CDH1 can also be found in the heart.54,55 In a genetic rat model of cardiac hypertrophy, the hypertrophic rats showed significantly higher levels of CDH1 compared to healthy rats, and this expression was particularly concentrated at the CM intercalated discs.55 This suggests that altered cell adhesion, through the expressions of cadherins, may play a role in cardiac hypertrophy.