In this sense, we have shown that the intratumoral infusion of the Delta-24-RGD followed by radiotherapy in preclinical models of pediatric high-grade glioma (pHGG) and DIPG led to superior survival due to the ability of the adenovirus to downregulate pivotal DNA damage repair proteins, thus sensitizing the glioma cells to the radiotherapy without deleterious effect to the viral replication. Here, PROS1 is linked to glioma.