They bind to the receptors on a postsynapticmembrane with a high affinity, leading to neural hyperactivation andconsequential death of the insect. Inaddition to the environmental aspect, neonicotinoids’ impacton human health has been recently studied and demonstrated to be involvedin breast cancer development by overexpressing the aromatase enzyme(CYP19). The gene discussed is CYP19A1; the disease is breast carcinoma.