However, in the multivariable Cox regression, both insulin-dependent and non-insulin-dependent DM were associated with similar HRs compared with non-DM patients: 1.44 (95% CI: 1.03–2.01, P = 0.031) and 1.48 (95% CI: 1.08–2.03, P = 0.015), respectively. The gene discussed is INS; the disease is diabetes mellitus.